Double-checking DNA synthesis
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چکیده
منابع مشابه
Double-checking DNA synthesis
Double-checking DNA synthesis T he replication and spindle assembly checkpoints work together to prevent premature mitosis, Magiera et al. report. Cells need to copy their DNA before they can separate their chromosomes. The DNA replication checkpoint monitors the progress of the first step, and the spindle assembly checkpoint (SAC) regulates the second. Still uncertain is how cells dovetail the...
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RATIONALE, AIMS AND OBJECTIVES Double checking is a standard practice in many areas of health care, notwithstanding the lack of evidence supporting its efficacy. We ask in this study: 'How do front line practitioners conceptualize double checking? What are the weaknesses of double checking? What alternate views of double checking could render it a more robust process?' METHOD This is part of ...
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Homologous recombination provides a mechanism of DNA double-strand break repair (DSBR) that requires an intact, homologous template for DNA synthesis. When DNA synthesis associated with DSBR is convergent, the broken DNA strands are replaced and repair is accurate. However, if divergent DNA synthesis is established, over-replication of flanking DNA may occur with deleterious consequences. The R...
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384 INSIGHTS | The Journal of Experimental Medicine Inhibition of DNA synthesis is a keystone of cancer therapy. The purine and pyrimidine precursors of DNA are obtained either by the de novo pathway (DNP) or the nucleotide salvage pathway (NSP). The DNP generates nucleotides that are reduced to the corresponding deoxynucleotide by ribonucleotide reductase (RNR). Thymidine, a potent inhibitor o...
متن کاملDouble checking the cross-check principle.
The cross-check principle was proposed by Jerger and Hayes over 20 years ago. Actually, the cross-check principle consists of a concept and a specific test protocol. The concept, that one test result confirms another test result, is still in use. Their specific protocol is essentially forgotten. The cross-check protocol they described, however, differs from more traditional test protocols. From...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2014
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2042iti1